From Athens the shortest route to Metsovo is along the National road Athens-Trikala (5 hours).
About one hour longer is the journey via Ioannina, following the opposite direction along the National Road Athens-Patra-Ioannina.
From Thessaloniki the shortest root is via Grevena (3 hours).
If you prefer avoiding driving, you can fly as far as Ioannina and then drive to Metsovo (1 hour). There is daily, two flights from Athens (55 minutes) to Ioannina and one flight from Thessaloniki (40 minutes) to Ioannina.
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