From the airport.
You can choose a transfer through the company Transvip or Transfer Delfo which charge between 7,000 to 8,000CLP. A good and cheap option is through the company Turbus or Centropuerto that they leave in the metro lines Pajaritos and Los Heróes. And the third option is through taxis or uber which has an average price of 15,000 CLP.
By Subway:
Take the subway to the Manuel Montt station. Walk down Manuel Montt street towards Inés de Suárez park, and turn right at Lorena street, at the end of that street is located tranqui Hostal.