From Hlavní nádraží (Main railway station) or bus station Florenc :
Metro line C, destination Chodov. The trip takes approx. 9-15 min.
From the airport:
By bus No. 119 to Dejvická metro terminal. Take metro line A, destination Muzeum; change for line C at the station Muzeum, destination Chodov. The trip takes approx. 50 min.